Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated; but not phosphorylated; by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718; ECO:0000269|PubMed:15563469; ECO:0000269|PubMed:17591767; ECO:0000269|PubMed:17911242; ECO:0000269|PubMed:18084323; ECO:0000269|PubMed:19345326; ECO:0000269|PubMed:20980437}.