NAD-dependent protein deacetylase; which deacetylates internal lysines on histone and non-histone proteins such as ACLY; PCK1 and RELA. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle; probably via its role in the regulation of cytoskeleton. Deacetylates PCK1; opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA (By similarity). {ECO:0000250}.