Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre- replication complex necessary to initiate DNA replication (By similarity). Binds histone H3 and H4 trimethylation marks H3K9me3; H3K20me3 and H4K27me3. Stabilizes LRWD1; by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3 (By similarity). {ECO:0000250}.